Frequently Asked Questions

A2M Injections


Alpha-2-Macroglobulin, or A2M is a naturally occurring molecule found in your blood that acts as a powerful protector against cartilage breakdown. A2M attaches to and removes the destructive enzymes, called proteases, that damage cartilage cells and tissues in the joint or disc space.

Why is an A2M injection a better solution for Osteoarthritis patients? 

An A2M injection contains a concentrated dose 6x more than what already occurs in your blood naturally. When this level of A2M is placed directly into your joint or disc space, it can provide proteases associated with cartilage cell and tissue breakdown within the joint or disc space.

Does an A2M injection have any other benefits?

Because this injection is derived from your own blood, it employs natural growth factors and bioactive proteins as a physiological agent to promote tissue growth and restoration of the affected joint.

What To Expect

Is an A2M injection painful?

No, the injection is not painful. The A2M solution is soothing to the joint same as it immediately starts to remove the harmful proteins.

Can I go back to work or daily activities?

Typical, you’ll be able to return to work the same day. Your physician will instruct you on any restriction based on your specific injury.

Should I ice after the injection? 

Icing the joint is not necessary after an A2M injection as it acts like an anti-inflammatory.

Will I need to wear a brace after the injection?

Not typically, however, your physician will instruct you on any necessary post-procedure care.

What can I expect after having an A2M Injection? 

You should follow your physician’s instruction about returning to normal activities, but the majority of patient can expect reduced inflammation within a few days of the injection. Total healing time is unique to your injury and your body’s recovery process and can take up to eight weeks to fully complete.

Will insurance cover the cost of an A2M injection?

No, insurance companies do not cover some of the newest technologies. You may pay cash, or use your private health saving account dollars or FSA Flexible Spending Plan.

How many A2M injections are needed?

The number of A2M injection needed depends on the type and severity of your injury. Your physician will determine the number of injections you should receive and the best timeline.


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